Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.
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Sinonasal and maxillary tumors were not included in the sample. MEC salivlaes composed of varying proportions of mucous, epidermoid, columnar, intermediate and clear cells Auclair et al. Salivary gland neoplasms, mucoepidermoid carcinoma, disease-free survival. Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site.
Inmunostaining for ki67 were made. However, remote access to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution.
Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
Thus, our findings may suggest the lack of association among clinicopathological features and the immunoexpression cardinoma c-erbB Remote access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use. All positive cases also expressed cytoplasmic staining.
Carcinoma ex pleomorphic adenoma of the salivary gland: There is a growing consensus that an aggressive surgical approach with adjuvant radiotherapy must always be considered for more advanced cases that present with a high histological grade, positive margins and cervical involvement.
Mucoepidermoid carcinoma of minor salivary glands: MEC is reported to manifest variable biologic aggressiveness, glandjlas showing correlation with its histological features and is graded by a 3-tiered system Auclair et al, University of Sao Paulo, Brazil.
The effects of age, gender, anatomic localization, carcnioma size, clinical stage, histological grade, recurrence, metastasis, compromised surgical margins and treatment on clinicopathological outcomes were investigated.
The three-level grading system commonly used ed pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth glsndulas cystic, solid, or infiltrativetogether with neural and vascular invasion. Am J Surg Pathol. Published works usually lose relevant survival information through time. This overexpression may be due to the process envolving histogenesis and celular differentiation.
Mucoepidermoid carcinoma of the salivary glands. Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. Disease-free survival rates were However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al.
The majority of MECs 27 cases were classified as low grade of malignancy. Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. MEC is the most common malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al. Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these locations mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al.
The tumoral histological grade was associated with the ki67 expression, relevant prognosis factors in MEC. Surgical resection was performed in all patients. Rare expression of the c-erbB-2 oncoprotein in salivary gland tumors: In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth df of life, whereas previous studies described a prevalence in fifth and sixth decades of life Auclair et al.
The c-erbB-2 oncoprotein is involved in matrix degradation and proteolitic activity as well as in the increase in vessel permeability, endothelial cell growth, proliferation, migration, and differentiation Verbeek et al. This abstract may be abridged. From oral biopsies submitted during period between and ,40 0. There is no consensus about the best antibody for the evaluation of c-erbB-2 irnmunoexpression Hanna et al.
Although MEC has been described as a radioresistant tumor, postoperative radiotherapy has been associated with decreased recurrence in some reports. Evaluation and application of grading criteria in cases.