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Brain cancer module: QLQ-BN Scope. The brain cancer module is meant for use among brain cancer patients varying in disease stage and treatment. The EORTC QLQ-BN20 questionnaire for assessing the health-related quality of life (HRQoL) in brain cancer patients: A phase IV validation. To be used in conjunction with the EORTC QLQ-C30 for measuring the health- related quality of life in patients with brain cancer.

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However, the evidence is not clear that a point threshold is applicable to each of the 15 QLQ-C30 scales [ 15 ]. These thresholds may also vary across patient eortd. Based on PS, our findings support the following integer estimates of the MCID for improvement and deterioration, respectively: Thresholds of 1 SEM have also been suggested [ 11 ].

EORTC QLQ-BN20 – EORTC Quality of Life Questionnaire – Brain Cancer Module

The QLQ-BN20 contains 20 items, 13 of which aggregate into four scales assessing future uncertainty, visual disorder, motor dysfunction MDand communication deficit. Skip to search form Skip to main content. Had we used a one-category change in the point Karnofsky performance scale, our results would probably differ. Using a variety of clinical classifications as anchors, King [ 14 ] came to similar findings after collating results from various studies and various cancer sites.

Furthermore, it has not yet been established whether the same thresholds apply to improvement and deterioration in HRQoL scores.

Therefore, to control for the amount of change in HRQoL that occurred to patients who did not change according to the anchor, we obtained estimates of the MCID by calculating the difference in mean HRQoL change between adjacent categories [ 11 ], i.

The association between HRQoL scores and anchor values and between changes in the anchor values and changes in the HRQoL scale were quantified by the Spearman’s rank correlation coefficient.

Cognitive function and fatigue after diagnosis of colorectal cancer. Meta-analysis provides evidence-based effect sizes for a cancer-specific quality of life questionnaire, the FACT-G.


Separate analyses were conducted for these two anchors.

Table 5 presents distribution-based MCID estimates for comparison with anchor-based estimates in Tables 3 and 4. This article has been cited by.

In an anchor-based approach, it is critical that the anchors be understandable and clinically significant. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of cancer therapy FACT anemia and fatigue scales.

Neoplasms Search for additional papers on this topic. Fortc both trials, HRQoL was measured as a secondary end point at baseline, during treatment, and on several follow-up occasions after the end of treatment. None, Conflict of Interest: For interpretation, it could be recommended to augment the anchor-based MCID estimates with results from one of the distribution-based approaches by considering only those anchor-based MCID estimates at least equal to 0.

In large sample sizes, statistically significant results can be obtained when numerical differences in HRQoL change scores are small and not likely to be clinically meaningful. Attention deficit hyperactivity disorder Primary malignant neoplasm of brain Bipolar Disorder pediatric intracranial germ cell brain tumor. Benchmarks eortd interpreting differences between groups cross-sectionally may differ from those for interpreting changes over qlq-n20 within q,q-bn20 [ 2 ].

This article has been cited by 1 Prospective assessment of quality of life in adult patients with primary brain tumors in routine neurooncology practice Budrukkar, A. In general, the anchor-based MCID estimates tended to be larger than the 0. J Can Res Ther ;2: There were major suggestions in three questions, which were incorporated into the second intermediate questionnaire to form the final Hindi BN questionnaire.

For permissions, please email: Other studies [ 1213 ] have also found only moderately strong correlations of the anchors with the HRQoL scores; the reason s are unknown. Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes.

EORTC Quality of Life Questionnaire – Brain Cancer Module (EORTC QLQ-BN20)

These estimates can be useful to clinicians to determine the proportion of patients benefiting from some treatment. Prognosis of advanced hepatocellular carcinoma: Based on these two studies, mean differences of 10 points or more are widely viewed as being clinically significant when interpreting the results of randomized clinical trials that use the QLQ-C30 [ 15 ].


Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: Claudia BitterlichDirk Vordermark Oncology letters Effects of radiotherapy on cognitive function in patients with low-grade glioma measured by the Folstein Mini-Mental State Examination. Fifteen patients improved their MMSE by 6 or more points and 33 patients deteriorated by 6 or more points and were excluded from further MMSE analyses.

A threshold of 0.

qls-bn20 Insufficient sleep and fitness to drive in shift workers: Note that patients could be categorized differently between the anchor and HRQoL measures, e. Content validation of the FACT-Br with patients and health care professionals to assess quality of life in patients with brain metastases. Molecular targeted therapies and chemotherapy in malignant gliomas.

Quality of life of lung cancer patients: In this study, changes in MMSE of 6 or more points were viewed as rather too large for the purpose of determining the MCID and were therefore excluded from the analysis, as were the changes in PS of two or more categories in order not to overestimate the MCID.

References Publications referenced by this paper. Another look at the half standard deviation estimate of the minimally important difference in health-related quality of life scores. The Mini-Mental State Examination in general medical practice: Trial 1 reported by Stupp et al. It will take a large number of such explorations to increase the confidence and familiarity of investigators.

Analysis pertaining qlq-bn0 physical and role functioning scales was restricted to Trial 1, which used version 3, the current version [ 19 ]. The remaining six single-item scales assess symptoms: Topics Discussed in This Paper. The two points furthest apart in time, denoted by T 1 and T 2provided a better chance of observing changes in HRQoL scores and were therefore used for analysis.