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Common Name: West African Rubber Tree. Funtumia elastica. Drawing of the leaves and flowers. Photograph by: Matilda Smith Public domain. Funtumia elastica (Preuss) Stapf [family APOCYNACEAE]. Common names. English West African rubber tree; Lagos silk rubber tree; bush rubber (Ghana. Description. Tree to 30 m tall; bole straight and cylindrical, crown narrow; bark brown to dark, thin, slightly fissured, becoming granular on old trees; Slash orange.

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Thus, related polysaccharides of various sizes comprise the Yam-I fraction.

Animal models of asthma. This is a PDF file of an unedited manuscript that has been accepted for publication. This page was last modified on 23 Februaryat Immunoregulatory functions of gamma delta T cells.

Requirement for gamma delta T cells in allergic airway inflammation. The publisher’s final edited version of this article is available at Int Immunopharmacol. Asthma is considered a T H 2 cell-mediated disease, funtumoa treatments that increase T H 1 responses can be effective in alleviating symptoms [ 54 ]. Interestingly, in models very similar to the peritonitis response we describe, such as an experimental sepsis model [ 48 ] and an E. HeJ mice Figure 5C, D.

Intraepithelial gamma delta T lymphocytes: QuinnMark A. Seven hours post-infection, mice were treated by i. In a peritonitis assay, C3H: The supernatant fluid was then filtered through a 0. Where presented, statistical significance was calculated using an unpaired, one-tailed t-test in Prism 5 GraphPad, Inc.


Antimicrobial and anti-inflammatory properties of Funtumia elastica.

Clearly, Yam-I functionally overlaps with LPS to some extent but the intestinal mucosa is constantly exposed to LPS from food, environment and normal flora. At present it is economically of no importance.

The manuscript will undergo copyediting, funtu,ia, and review of the resulting proof before it is published in its final citable form. Skin gammadelta T-cell functions in homeostasis and wound healing. Navigation menu Personal tools Log in Request account. Both prophylactic and post-exposure strategies involving innate immune stimulation by adjuvants have been shown to prevent or ameliorate infections [ 4445 ].

Antimicrobial and anti-inflammatory properties of Funtumia elastica.

These smaller fractions, which were difficult to generate, were used for limited in vitro assays. Lines in Figure 2 represent the average relative gene expression levels of genes that changed at funtujia 1.

Briefly, the extracts were mixed with anthrone reagent 0. The only published characterizations of Funtumia elastica describes the isolation of steroidal alkaloids from its leaves and bark with antiplasmodial [ 52 ] or antifungal activity [ 53 ].

Toth GB, Pavia H. Very low concentrations of Yam-I drove neutrophil recruitment peritonitis in mice that was partially tolllike receptor 4 TLR4 – and myeloid differentiation primary response gene 88 MyD88 -independent, suggesting a mechanism unique from that of LPS.


Adverse functions of ILA in experimental sepsis. Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Around there were large plantations in Ghana, Nigeria and Cameroon.

Thus, we considered whether the active component was present in the polysaccharide fraction, as polysaccharides derived from various medicinal plants have been shown previously to have immunomodulatory activity and can be large in size [ 38 ].

The carboxyfluorescein succinimidyl ester CFSE assay for human cells has been recently described [ 1 ]. Representative of at least 3 experiments with different donors. Briefly PBMCs from human donors were labeled with 2. The floss of the fruits is used like kapok, to stuff cushions. Cells were plated 2. Funtumiw role of exogenous IL Retrieved from ” https: A colorimetric method for the determination of sugars.

HeJ mice were treated funtumiw the 3 sub-fractions of Yam-I in a priming assay, and proliferation was measured using CFSE staining in flow cytometry.